Wound Closures using Hot Glue Gun and Custom Biocompatible Glue

Sutures and staples are the alternatives used for closing soft tissue wounds and incisions generally. However, a major pitfall of such methods is the scars and marks that they leave behind, which is unpleasant for the patients to have to deal with. Specialty adhesives are also used to fuse tissues together, but only in certain cases, particularly in cosmetic surgery. The downside to them is that they tend to solidify into a harder form than the native tissue and can also be toxic.

Addressing this issue, soft biocompatible glue, and an accompanying glue gun, that can close wounds and incisions quickly and easily, and which does not cause toxic side effects has been created by researchers from -Israel Institute of Technology.

A biocompatible material that has a low melting point and continues to remain soft when in a solid state; called N- hydroxyl succinimide- modified polycaprolactone is used in the glue, four- armed. The material is inserted like a stick and pushed forward, very similar to a traditional glue gun. Pressure is applied as the tip of the material is heated which makes it melt and helps it seep out the barrel. This way the glue gets to be applied at the appropriate spot into the wound. An intuitive technique aids in doing so.

An interesting fact about this glue is that depending on its requirement and the situation of the wound, its recipe can be altered. Aspects such as different melting points, soft or hard, less or more stickier can be decided prior to its application. Thus the material can be ordered as it is required by the clinicians or it can be prepared in- house as well.

In vitro and in vivo experiments have shown biocompatibility and safety in animals; however, clinical studies of the glue gun and its glue have yet to be performed.

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